Erectile dysfunction is the inability to achieve and maintain an erection adequate for intercourse to the mutual satisfaction of both the partners. Due to Erectile dysfunction both partners in a relationship are affected. The brain control all the sexual function and controlling the hormonal (like Testosterone), psychological and blood flow to the penile organ that lead to an erection. There are various causes of ED such as fatigue, anxiety, depression, guilt, stress, excessive alcohol consumption, hormonal insufficiency, diabetes mellitus, and cardiovascular diseases. Viagra is the most popular of the PDE5 inhibitors. Viagra has been around the longest and having the long term safety data. Viagra is also administered in higher doses among other PDE5 inhibitors.
Mechanism of Action
Nervous system stimulates the penile shaft and thus leads to secretion of nitric oxide which in turn responsible for the secretion of cGMP. The cGMP has the potential to relax blood vessels (vasodilation), the corpus cavernous fill with the blood and subsequently cause a penile erection. PDE-5 presents in the penis and causes the destruction of cGMP level and thus resulting in loss of erection. Viagra is the PDE-5 inhibitor which causes inhibition and helps in regaining of cGMP level and finally responsible for achieving adequate erection for satisfaction.
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